SMAD4 promotes TGF-β-independent NK cell homeostasis

sma4dEvans and colleagues describe a novel immunomodulatory function of semaphorin 4D (SEMA4D) and show that blocking SEMA4D enhances immune infiltration into tumorSMAD4 is the only common SMAD in TGF-β snaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here that